清肺排毒汤

Qingfei Paidu Decoction for COVID-19

Qingfei Paidu Decoction was made by National Administration of Traditional Chinese Medicine, based on the core pathogenesis of COVID-19. This medicine is combined with the innovative prescriptions in "Treatise on Febrile and Miscellaneous Diseases" which is a very famous Chinese traditional medical book since 2000 years ago. This medicine can be used to treat patients with mild, common and severe pneumonia infected by COVID-19, and it can also be used reasonably in the treatment of critically ill patients based on the actual conditions of the patients. This medicine is for disease treatment and is not recommended for purpose of preventing disease.

After clinical observation of the treatment of confirmed patients in Shanxi, Hebei, Heilongjiang, and Shaanxi province of China, this prescription has obtained more than 90% efficiency. On February 6th, National Health Commission and National Administration of Traditional Chinese Medicine promoted  this prescription in nationwide. 

【Ingredients】

"Qingfei Paidu Decoction" is derived from the four classic prescriptions in the traditional Chinese medicine classic book of "Treatise on Febrile and Miscellaneous Diseases" since 2000 years ago. The main ingredients involve Ma Huang (Ephedrae Herba), Zhi Gan Cao (Glycyrrhizae Radix), Xing Ren (Armeniacae Semen), Sheng Shi Gao (Gypsum fibrosum) (decocted first), Gui Zhi (Cinnamomi Ramulus), Ze Xie (Alismatis Rhizoma), Zhu Ling (Polyporus), Bai Zhu (Atractylodis macrocephalae Rhizoma), Fu Ling (Poria), Chai Hu (Bupleuri Radix), Huang Qin (Scutellariae Radix), Jiang Ban Xia (Pinellinae Rhizoma Praeparatum), Sheng Jiang (Zingiberis Rhizoma recens), Zi Wan (Asteris Radix), Kuan Dong Hua (Farfarae Flos), She Gan (Belamcandae Rhizoma), Xi Xin (Asari Radix et Rhizoma), Shan Yao (Dioscoreae Rhizoma), Zhi Shi (Aurantii Fructus immaturus), Chen Pi (Citri reticulatae Pericarpium), Huo Xiang (Pogostemonis Herba). The four classic prescriptions and functionality are as below:

  1. Ma Xing Ganshi Decoction (Ephedra, roasted licorice, almonds, raw gypsum)

    Ephedra dispels the surface and spreads the lungs, opens the pores of the whole body, and allows the heat evil in the lungs to escape from the fur; almonds strengthen the lung suppression function, and the lungs and the large intestine are aligned with each other, driving the heat in the lungs to the large intestine and out of the large intestine; It can not only clear heat but also produce body fluid. Plaster reduces the fire in the stomach, lungs and large intestines. It can also release the fire in the body from urine and stool; then licorice can save body fluid, strengthen the body, and replenish the spleen and stomach.

  2. Wulingsan (Polyporus, Poria, Atractylodes, Alisma, Guizhi)

    The damp evil is the culprit of this plague, and the damp evil is the hotbed of the new crown virus. But removing dampness can't hurt the yang, so I used Wulingsan to warm the yang to reduce dampness. Wenyang conserves water, on the one hand warms the sun, on the other hand directly conserves water. Warming Yang is to help cure the root cause, while benefiting water is to attack evil and cure the symptoms.

  3. Xiaochaihu Decoction (Bupleurum, Scutellaria, Pinellia, Licorice, Ginger)

    Chaihu Decoction has three groups of medicines. The first group of medicines: Bupleurum and Scutellaria: to open up the half-surface and half-inner area, let the evil spirits go out, and remove the fire of liver and gallbladder; the second group of medicines: Banxia. Pinellia in this recipe is mainly used to reduce adverse effects; the third group of medicines: ginseng, ginger, roasted licorice, and jujube (no one is involved in jujube in Qingfei Paidu Decoction). These four medicines all enter the spleen and stomach. It can quickly replenish the body fluid of the spleen and stomach. As long as the function of the spleen and stomach is restored, a steady flow of qi and blood will be produced to fight the pathogenic diseases.

  4. Shegan Mahuang Decoction (Shegan, Ephedra, Ginger, Asarum, Aster, Coltsfoot, Pinellia)

    Cough is one of the most important symptoms of new crown patients. Many medicines in it are used to relieve phlegm and relieve cough, such as coltsfoot, Pinellia ternata, aster, ephedra and asarum for lungs, and pungent warming. Shegan is used to clear the throat and relieve the throat swelling and pain caused by heat toxins.

  5. The rest ingredient of the Qingfei Paidu Decoction are four kinds of herb: yam, ZhiShi, tangerine peel, and HuoXiang. Yam is used to strengthen the body, to protect the spleen and stomach, and to prevent this recipe from being a bit warm and dry. Citrus aurantium is used to relieve chest tightness, breathe, and break the breath, and at the same time make the patient's stool smoother. Tangerine peel and Huoxiang are used to dehumidify and aromatize dampness. Huoxiang has a high rate of appearance in this epidemic. Chenpi and Huoxiang can also solve the patient's gastrointestinal discomfort, such as abdominal distension and diarrhea.

【Usage】

Soup of traditional Chinese medicine, take in the morning and evening (forty minutes after meals) with warm water, three days for a period of treatment. If possible, you can add half a bowl of rice soup each time you finish taking the medicine, and you can take up to one bowl for those with dry tongue and body fluid deficiency. (Note: If the patient does not have a fever, the amount of gypsum should be small, and the amount of gypsum can be increased for fever or strong heat). If the symptoms improve but not cured, take a second course of treatment. If the patient has special conditions or other underlying diseases, the second period of treatment can be modified according to the actual situation, and the drug will be stopped if the symptoms disappear.

【Chemical Analysis】

The research team of the Naval Military Medical University and the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences jointly carried out research on the pharmacodynamic material basis and mechanism of action. The data showed that the 21 traditional Chinese medicines of this prescription have 16 flavors to the lung meridian, and the rest of the traditional Chinese medicines cooperate to protect the heart, liver, spleen, stomach and kidneys. At present, the identification of more than 300 chemical components and more than 200 blood components has been completed, and 790 potential targets have been predicted, proving that "Qingfei Paidu Decoction" can play an overall regulatory role on the body through multiple components and multiple targets. The entire pathway of COVID-19 from viral invasion and viral replication to secondary inflammatory factors causing multiple organ damage, so as to improve clinical symptoms, avoid or alleviate inflammatory storms, adjust and improve the internal environment of the body, enhance the ability to remove viruses, and reduce feel the risk of recurrence.

【Clinical effect】

Combined with the clinical observations of doctors in many places of China, this prescription is suitable for light, common and heavy patients, and can be used reasonably in the treatment of critically ill patients in light of the actual conditions of the patients.

Resource: National Administration of Traditional Chinese Medicine

On April 17, 2020, the State Council’s Joint Prevention and Control Mechanism held a press conference. Wang Wei, vice president and professor of Beijing University of Chinese Medicine, and academician of the International Eurasian Academy of Sciences attended the press conference and answered reporters’ questions.

Regarding the clinical application of Qingfei Paidu Decoction, Wang Wei said that through various clinical observations and preliminary basic research, it has been shown that Qingfei Paidu Decoction is a general prescription suitable for patients with mild, common and severe COVID-19, with quick-acting and high-efficiency , Safety features. He believes that Qingfei Paidu Decoction is a special medicine for the treatment of COVID-19, and welcomes domestic and foreign researchers to compare Qingfei Paidu Decoction with other treatment methods.

Wang Wei introduced that on January 27, the State Administration of Traditional Chinese Medicine urgently launched the prevention and treatment project of Chinese medicine for the prevention and treatment of COVID-19 based on clinical emergency, practicality and utility. First, emergency clinical observations were conducted in Shanxi, Hebei, Shaanxi, and Heilongjiang provinces. The first batch of 214 patients of different ages was observed, and preliminary observations found that the effective rate was above 90%.

At present, Qingfei Paidu Decoction has been included in the sixth and seventh editions of the diagnosis and treatment plan. It is currently the only general treatment formula and has been widely used in 28 provinces and cities across the country. It has received relatively good results and has become a new crown of prevention and treatment. An important means of pneumonia.

Wang Wei said that while clinically treating patients with COVID-19, clinical observations have been carried out in 66 designated units in 10 provinces and cities. As of 0:00 on April 12, of the 1262 patients admitted, 1,253 have been cured and discharged, accounting for 99.28%. In these 1262 cases, there were no cases of mild to severe and ordinary to critical, which blocked the patient's development to the critical aspect.

From clinical observations, the National Medical Insurance Bureau recently announced that the per capita treatment cost for severely ill patients with COVID-19 exceeded 150,000, and the use of Qingfei Paidu Decoction for a course of treatment is very cost-effective, which is also a great saving in medical insurance expenses.

In the observation of 133 confirmed patients in Shanxi Province, 103 patients used Qingfei Paidu Decoction. The clinical symptoms improved significantly, and all the fever symptoms disappeared within 3 days. After 6 days of treatment, the absorption of lung CT lesions was also very obvious. In addition, the negative rate of nucleic acid is 100%, and the average negative time is about ten days.

In the preliminary observation of 548 suspected patients in Shanxi Province, 187 cases of Qingfei Paidu Decoction were used, of which only 10 cases were converted to confirmed cases, accounting for 5.35%; a total of 123 suspected patients who did not use Qingfei Paidu Decoction were converted to confirmed cases Cases, accounting for 34.17%. Wang Wei said that the results can initially suggest that the Qingfei Paidu Decoction intervenes in special populations, and there are signs of a positive effect in reducing the incidence of groups.

Wang Wei introduced that Qingfei Paidu Decoction is the most used prescription in the main battlefield of Wuhan, Hubei. Many companies actively participated and prepared and distributed a large number of prescriptions for free. Since February 5, a total of 390,000 bags of decoction have been distributed to designated hospitals and isolation points in Wuhan, and 500,000 doses of compound granules have been distributed to Hubei province of China.

【Case in worldwide】

After the outbreak of the European epidemic, the supply of Chinese medicines to fight the plague and enhance the immune function was in short supply. The Oriental National Medicines recently produced the [Humidity and Anti-Plastic Drink] to meet the market demand of European people.

Hungary actively carried out the implementation and promotion of Chinese medicine: built the first Chinese medicine factory that meets EU standards, became the first European country to implement Chinese medicine legislation, established the first Confucius Institute with Chinese medicine characteristics in Europe, and established the first Qihuang in Central and Eastern Europe Traditional Chinese Medicine Center and Central and Eastern European Traditional Chinese Medicine Cultivation Base... Chinese medicine cooperation has become a new highlight of China-Hungary cooperation.

Former Hungarian Prime Minister Megyesi once said: "China's achievements in fighting the epidemic are obvious to all. An important reason is the good integration of traditional Chinese medicine and Western medicine." Succi Gezo, chief adviser to the Prime Minister of Hungary, said at the event in August. The wisdom and methods of traditional Chinese medicine culture have successfully helped Hungary become one of the most outstanding and successful countries in Europe in the fight against the new crown epidemic. "Cultivating Earth and Generating Gold" takes the people as the soil, takes root, builds and shares a community of human health, and has integrated Chinese medicine into the lives of millions of local people.

Pre-co-Flu (Pre-co-Flu) is developed by the Hungarian Oriental Sinopharm Group Qihuang Traditional Chinese Medicine Center, according to the National Health Commission and the provincial TCM diagnosis and treatment guidelines, according to local people's physical fitness, eating habits, climate and other factors. In Central and Eastern Europe, during the winter and spring of the onset, many people first had gastrointestinal symptoms, first had abdominal pain, diarrhea, nausea, vomiting and other symptoms, and then some people had upper respiratory symptoms such as fever and cough. Some people have no symptoms of fever, so turmeric is added to the prescription to reconcile the spleen and stomach, promote qi to clear blood stasis, and relieve menstruation and pain. And added perilla leaves and Su stems that can relieve the surface and dispel cold, promote qi and stomach, detoxify and reduce dampness. Pre-co-Flu (Pre-co-Flu) has the effects of invigorating the lungs and preventing blasts, relieving the surface and removing dampness, dispelling wind and stomach, replenishing qi and solidifying the surface, improving the circulation of qi and blood, and enhancing immunity.

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